Yes. Osteogenesis imperfecta, or oi for short, is caused by genetic mutations of certain collagen genes. There are a number of types, and the severity can range from lethal shortly after birth to quite mild. Bone fractures, sometimes dental problems, and sometimes hearing loss can occur. The oi foundation is a great source of information: http://www. Oif. Org/site/pageserver.
It is. A chronic disease.
Time issues. The issue as defined is simple. An acute disease is something like appendicitis, it comes up quick, you fix it or die. A chronic disease is something that may become evident slowly, but once found, is just managed (like arthritis) to make life as tolerable as possible. OI has many forms related to genetic defects in the formation of bone. It exists from conception but becomes evident later.
Read my answer. So, oi has been noted in skeletons that date back to antiquity (egypt, specifically). The disease is also known as lobstein disease. There were actually a few lobsteins, german-french surgeons and anatomists in the late 18th and 19th centuries. The classification for oi is attributed to david sillence, an australian geneticist and an authority on the disease.
YES... This is a condition that affects all bones in the body - with a great degree of variability amongst patients in the severity of the disease. There are several types known, and symptoms are quite different depending on the type. What is common is the brittle bone - in mild forms the fractures occur in childhood and stop after adulthood. Some patients have hearing loss/tooth problems.
YES. Blue sclera, poor muscle tone, early loss of hearing in some children, slight protrusion of the eyes.
Yes it can. OIhas many different subtypes, some are more limited dot bone while others involve additional tissues. The problem in OI is with COLLAGEN an important building block protein in many living structures and tissues in many species. OI has now 8 different subtypes http://www. Oif. Org.
No. Bone marrow stem cells and osteoblast progenitors (the cells that make bone) are derived from a common cell. After bone marrow transplant, new bone forming cells come from the engrafted marrow, not the cells from the recipient. So, if someone with oi donates marrow, the reciepient would also get oi along with the marrow, at least as far as new bone formation is concerned. Not a good option.
Are the bones of individuals having osteogenesis imperfecta will become more brittle as they reach the age of 40 and above?
Deformities due to. Bones remain brittle and as you age there are deformities dure to repeated fractures, there are different kinds from type1 to type8.