Depends on the chemo. Herceptin should not be given in combination with adraimycin. It would increase the risk of heart toxicity. We do commonly give Herceptin in combination with other drugs like Carboplatin and taxotere, or paclitaxol in an adjuvant setting. Herceptin alone is done to complete 1 year of treatment. In the setting of advanced disease we give it in combination with drugs like Xeloda and navelbine (vinorelbine).