9 doctors weighed in:
When does screening for down's syndrome begin?
9 doctors weighed in

Dr. Brian Enggano
Obstetrics & Gynecology
2 doctors agree
In brief: First trimester
Screening for down syndrome can begin as early as 11-14 weeks during the first trimester using a blood test and measurements on an ultrasound.
Additional screening tests can be performed in the second trimester (~15-20 weeks) to add specificity to the testing. Together, the tests can detect down syndrome with greater than a 95% detection rate.

In brief: First trimester
Screening for down syndrome can begin as early as 11-14 weeks during the first trimester using a blood test and measurements on an ultrasound.
Additional screening tests can be performed in the second trimester (~15-20 weeks) to add specificity to the testing. Together, the tests can detect down syndrome with greater than a 95% detection rate.
Dr. Brian Enggano
Dr. Brian Enggano
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Dr. William Singer
Pediatrics - Neurology
2 doctors agree
In brief: Downs syndrome
Recent reports indicate there is a blood test that can determine downs syndrome very early in the pregnancy.
The standard approach has been amniocentesis done between 12 and 16 weeks of the pregnancy. Additional tests include a non invasive echo looking for nuchal folds chorionic villus testing.

In brief: Downs syndrome
Recent reports indicate there is a blood test that can determine downs syndrome very early in the pregnancy.
The standard approach has been amniocentesis done between 12 and 16 weeks of the pregnancy. Additional tests include a non invasive echo looking for nuchal folds chorionic villus testing.
Dr. William Singer
Dr. William Singer
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Dr. Karl Muench
Clinical Genetics
2 doctors agree
In brief: At 10 weeks...
...First trimester maternal serum testing and nuchal translucency by fetal ultrasonography begin and can be followed by the maternal serum quad testing for a combined detection rate of 95% with 5%-8% false positives.
These non-invasive test results can be validated by chorionic villus sampling (cvs) at about 10 or by amniocentesis at about 15 gestational weeks.

In brief: At 10 weeks...
...First trimester maternal serum testing and nuchal translucency by fetal ultrasonography begin and can be followed by the maternal serum quad testing for a combined detection rate of 95% with 5%-8% false positives.
These non-invasive test results can be validated by chorionic villus sampling (cvs) at about 10 or by amniocentesis at about 15 gestational weeks.
Dr. Karl Muench
Dr. Karl Muench
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Dr. James Ferguson
Pediatrics
In brief: Depends on interest
The NIPP is a non-invasive test that examines fetal cells in mother's blood.
While promoted as a paternity test, it can be used as an accurate way to detect chromosome abnormalities like DS as early as 8 weeks into pregnancy. Less accurate screening tests like ultrasound are not invasive but less definite and done later.Amniocentesis done at 16 weeks is definite but invasive. Some mothers don't

In brief: Depends on interest
The NIPP is a non-invasive test that examines fetal cells in mother's blood.
While promoted as a paternity test, it can be used as an accurate way to detect chromosome abnormalities like DS as early as 8 weeks into pregnancy. Less accurate screening tests like ultrasound are not invasive but less definite and done later.Amniocentesis done at 16 weeks is definite but invasive. Some mothers don't
Dr. James Ferguson
Dr. James Ferguson
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