What is my risk for ovarian cancer is I have the brca-1 gene?

54 % Women with a brca1 mutation have a 54% of getting ovarian cancer during their lifetime. This risk can be reduced to less than 5% by having both ovaries removed.
About 55% The lifetime risk of ovarian cancer with a harmful brca1 gene mutation is about 55%.

Related Questions

Hi, can you recommend a company that can test me for the brca 1 and 2, that offers international service? My mother died from ovarian cancer at age 57

Not that simple. Just your mother's ovarian cancer is not enough to qualify, for genetic screening. Have to meet other criteria myriad genetic lab has patent on brca I & ii testing, through your doctor out side usa can be tested, by contacting mblom@myriod. Com and it is expensive (most of med insurances will not cover).

I have pubic bone pain and urinary frequency. Doctor ordered a transvaginal ultrasound that came back clear. Could it be ovarian cancer? (age28, brca)

Probably not. It is very unlikely to have ovarian cancer at 28yo. A negative ultrasound doesn't necessarily rule it out but is a good indicator that the ovaries are ok at this time. If you are brca positive, then you should have an ultrasound and ca125 test every 6 months which may help a little but even better is to remove ovaries once you have completed your family.

About the brca-1 gene (breast cancer gene)...If a male is a carrier for the gene what will happen to his daughters?

50:50 inheritance. Any child of a brca carrier has a 50:50 chance of inheriting that mutation. If they have inherited the mutation, they have a 50-80% chance of developing breast cancer, and an increeased risk of several other cancers. For more information, check this link: http://www. Cancer. Gov/cancertopics/factsheet/risk/brca.
50% chance. Each child of a father carrying a brca mutation has a 50% chance of having the same mutated gene. If a daughter has the brca1 mutation, she will have a higher chance of developing breast and ovarian cancer at an early age. Any child of a parent with a brca mutation should have genetic counseling and testing before childbearing age.
50% Each child of a brca mutation carrier has a 50/50 chance of getting the mutation regardless of gender. We usually test them for only that particular mutation (single site analysis) which is cheaper. Word of warning: two individuals with two different mutations can be married and then each child can inherit none, one, or both. We need to know the family history of both sides of the family.

What genes cause hereditary ovarian cancer?

BRCA 1 and 2. The breast-ovarian cancer (brca 1 and 2) genes are the only ones so far proven to cause susceptibility to ovarian cancer (as high as 50% lifetime risk for ovarian, 85% for breast cancer if you have a mutation. Other ovarian cancer susceptibility genes may be identified by ongoing research.
BRCA 1 and BRCA 2. Your healthcare provider needs to be aware of your family history to be able to assess risk of certain cancers and to determine if genetic testing is appropriate. Having a brca mutation increases your risk of breast and ovarian cancer. Being aware of your cancer risk allows the opportunity to take action to prevent cancer.

Why won't insurance cover blood tests to see if you carry the ovarian cancer gene?

Do You Qualify? Many insurances (including medicare) will cover the expense for brca testing, provided that a person has a 10% chance, or greater, of having the mutation. A risk estimate can be calculated by your age, personal history of cancer, and age and type of cancer in first-degree relatives. A risk calculator can be found on the website for the company that performs this blood test, myriad genetics.
Cost. It is not cost effective to screen every person for these genes who do not have a suggestive family history.
Most will. Most insurances will cover testing of the breast and ovarian cancer genes (brca 1 & 2) as long as your risk is high enough to justify the testing. If you have ovarian cancer, or if multiple family members have had breast and/or ovarian cancer, especially at an early age, or if there is ashkenazi jewish heritage, most insurance carriers will cover the test.

Should I screen my children for ovarian cancer genes since it seems to be so deadly? There is no history in my family.

No. There is no simple screen for ovarian cancer susceptibility beyond the breast-ovarian cancer gene (brca) testing that costs $2600-3300. Only families with cases of ovarian or early onset (<45) breast cancer should consider this testing.
Cancer screening. Even though deadly- without a family history - screening has not been proven to be beneficial either from a survival or economical standpoint. Definitely there are ovarian cancers that are part of the genetically predisposed (brca etc), but these are associated with definitive family involvement. Age and hormone exposure are also related to increased risk.
No. Testing for cancer genes is a very important part of cancer risk assessment and prevention. Family history is the tool that is used to determine if someone needs testing. If their is no family history then you do not need to test.

Can doctors do blood tests to see if you carry the ovarian cancer gene?

Yes, we can order. Yes, we can order blood test for brca 1/2. However I think prior to blood test you should have a genetics counselling either by a genetic counsellor or your doctor - so you understand the impact /implication of positive or negative finding of your test. Discuss further with your physician.
Yes-BRCA Test. While the test is easy to perform, the ramifications of the results are not. It is best to meet with a genetic counselor before getting this test to see if you qualify and understand how the results might affect you and your family's medical options. For more information including testing criteria, check the website of the test manufacturer, myriad.
No one gene. A number of genetic anomalies increase the risk of ovarian cancer but there is not a single or even a set of tests, that would be useful in isolation. You may wish to discuss your family history with your doctor to see if a genetic test is warranted.

What's my likelihood of having the mutated genes if three people in my family have have breast and ovarian cancer? They were my nan and her sisters

High risk. You are definitely at risk and should seek genetic counseling. You should also let us know if you have any older sisters as your siblings.
Suspicious. It is difficult to tell you odds without having more details regarding your family history but I have to say it is quite suspicious. You can see a specialist in risk assessment and genetics but ideally the test should be done first in affected individuals, preferably the one with ovarian cancer or the youngest to get breast cancer (assuming they are alive). Best to you.