14 doctors weighed in:

What happens genetically that causes chronic myelogenous leukemia?

14 doctors weighed in
Dr. Stephen Noga
Internal Medicine - Oncology
12 doctors agree

In brief: Translocation

A big word but dna is always recombining when cells divide.
In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme.

In brief: Translocation

A big word but dna is always recombining when cells divide.
In this case, a piece of dna from chromosome 9 moves over to chromosome 22 which essentially turns on a switch that produces an enzyme that promotes uncontrolled cell division and leukemia. Modern drugs are targeted to prevent the action of this enzyme.
Dr. Stephen Noga
Dr. Stephen Noga
Thank
1 comment
Dr. Sahba Ferdowsi
Good answer. Wishing you'all the very best.
Dr. Agos Luca
Pathology

In brief: See below

CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome.
This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain.

In brief: See below

CML is a type of leukemia caused by a genetic abnormalty, namely a translocation between chromosomes 9 and 22 resulting in the philadelphia chromosome.
This leads to a fusion of two genes, bcr ; abl, and the fusion product stimulates the proliferation of myeloid cells uncontrolably. However, the exact cause of the translocation itself is uncertain.
Dr. Agos Luca
Dr. Agos Luca
Thank
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