10 doctors weighed in:

What gene causes hemophilia a, how is it inherited?

10 doctors weighed in
Amanda Xi
General Practice
8 doctors agree

In brief: Gene for Factor VIII

Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting).
It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms.

In brief: Gene for Factor VIII

Hemophilia a is a hereditary bleeding disorder where there is a deficiency in clotting factor viii (factor viii is needed for blood clotting).
It is inherited on the x-chromosome (sex-linked). Men only have 1 "x", so if their "x" is mutated, they will have the disease. Women have 2 "x's", so they can have 1 mutated "x" and 1 normal "x", and be a carrier of the disease, with mild or no symptoms.
Amanda Xi
Amanda Xi
Answer assisted by Amanda Xi, Medical Student
Thank
Dr. Maurice Atiyeh
Internal Medicine - Gastroenterology

In brief: X-chromosome defect

Hemophilia A is due to an inheritance of a defective x-chromosome either lacking (Factor V111 ), the normal clotting protein, or carries a defective gene .
A rare female having hemophilia must have the defect in 2 of her X chromosomes. Her daughter inherits one of them but since she gets a second normal chromosome from her father,she is protected, .A son gets a Y chromosome from his father,

In brief: X-chromosome defect

Hemophilia A is due to an inheritance of a defective x-chromosome either lacking (Factor V111 ), the normal clotting protein, or carries a defective gene .
A rare female having hemophilia must have the defect in 2 of her X chromosomes. Her daughter inherits one of them but since she gets a second normal chromosome from her father,she is protected, .A son gets a Y chromosome from his father,
Dr. Maurice Atiyeh
Dr. Maurice Atiyeh
Thank
Get help from a real doctor now
Dr. Marsha Davis
Board Certified, Internal Medicine
25 years in practice
67M people helped
Continue
111,000 doctors available
Read more answers from doctors