2 doctors weighed in:

How often is prenatal screening wrong?

2 doctors weighed in
Dr. James Ferguson
Pediatrics

In brief: Screening/definitive

This would depend on the level of the test.
The most accurate are things like the non invasive prenatal screening (NIPS) done on maternal blood at under 10 wks which correlates highly with amniocentesis ( a definitive). The screening tests using ultrasound or blood chemical studies are less so.

In brief: Screening/definitive

This would depend on the level of the test.
The most accurate are things like the non invasive prenatal screening (NIPS) done on maternal blood at under 10 wks which correlates highly with amniocentesis ( a definitive). The screening tests using ultrasound or blood chemical studies are less so.
Dr. James Ferguson
Dr. James Ferguson
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Dr. Golder Wilson
Clinical Genetics

In brief: Often if quad screen

Maternal serum screening with three (triple test) or quad (four markers), when combined with ultrasound (integrated screen) will detect about 88% of fetuses with down syndrome--however, there are many false positives (abnormal when fetus is normal) and even more false negatives (normal screen when fetus has down syndrome or another chromosome aberration.

In brief: Often if quad screen

Maternal serum screening with three (triple test) or quad (four markers), when combined with ultrasound (integrated screen) will detect about 88% of fetuses with down syndrome--however, there are many false positives (abnormal when fetus is normal) and even more false negatives (normal screen when fetus has down syndrome or another chromosome aberration.
Dr. Golder Wilson
Dr. Golder Wilson
Thank
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