Maybe but it depends. I can't answer your question exactly b/c you didn't specify NSAID or antihistamine. Check out both www. Online. Epocrates. Com & www. Drugs. Com to check for medication interactions. Plug in what you're taking and both websites will warn you of possible interactions. They're not 100% foolproof but they're a good start. Better yet, ask whoever prescribed your meds. Always tell ur doc what you're taking!