10 doctors weighed in:

How does inheritance of a mitochondrial disease work?

10 doctors weighed in
Amanda Xi
General Practice
7 doctors agree

In brief: Maternal and Regular

A few mitochondrial diseases are passed from the mother to all of her children.
This is because certain mitochondrial genes are inherited from the mitochondria in the egg's cytoplasm (outside the "nucleus" that contains the regular genes). Other mitochondrial diseases are inherited the regular way, from the genes in the egg "nucleus" and in the sperm, that code for new mitochondria in the embryo.

In brief: Maternal and Regular

A few mitochondrial diseases are passed from the mother to all of her children.
This is because certain mitochondrial genes are inherited from the mitochondria in the egg's cytoplasm (outside the "nucleus" that contains the regular genes). Other mitochondrial diseases are inherited the regular way, from the genes in the egg "nucleus" and in the sperm, that code for new mitochondria in the embryo.
Amanda Xi
Amanda Xi
Answer assisted by Amanda Xi, Medical Student
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1 doctor agrees

In brief: Multifactorial

All of your mitochondria come from the mother. Control of mitochondrial function is, however, influenced by nuclear DNA (the DNA that comes from both parents).
Abnormal mitochondria present in the egg can randomly segregate during cell division and embryogenesis so that many or few organ systems are involved. The impact depends on the proportion of abnormal mitochondria and the locations. http://www.umdf.org/site/c.8qKOJ0MvF7LUG/b.7934627/k.3711/What_is_Mitochondrial_Disease.htm

In brief: Multifactorial

All of your mitochondria come from the mother. Control of mitochondrial function is, however, influenced by nuclear DNA (the DNA that comes from both parents).
Abnormal mitochondria present in the egg can randomly segregate during cell division and embryogenesis so that many or few organ systems are involved. The impact depends on the proportion of abnormal mitochondria and the locations. http://www.umdf.org/site/c.8qKOJ0MvF7LUG/b.7934627/k.3711/What_is_Mitochondrial_Disease.htm
Dr. Lois Freisleben-Cook
Dr. Lois Freisleben-Cook
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