8-10% The prevelance of sickle cell trait in african americans is thouight to be about 8 to 10 percent. It may be as high as 25 to 30 percent in certain parts of western africa.
Sickle trait common? In the United States about 3 million have sickle cell trait (source www. Sicklecelldisease. Org). In african americans, approximately 1 in 12 carry the sickle cell trait.
Hemoglobinopathy. Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms.
Gene mutation. Sickle cell trait is caused bu the presence of a single mutation in the beta chain of human hemoglopin a gene. A mutation in one gene on one of a person's two beta globin genes results in sickle cell trait (sa hemoglobin) while the same mutation in both of a persons genes causes sickle cell anemia. (ss hemoglobin). The term trait means a carrier for the sickle cell mutation.
Proper care needed. As long as they are under proper medical attention there should be no problem.
My spouse is a carrier of the trait but I am not. What are the chances of our kids having sickle cell disease?
Zero if..... If you are not a trait carrier & do not have sickle cell, the pregnancies you make will never produce sickle cell disease. If you are really normal, the two possibilities would be trait or normal.
None. If you know for sure that you are not a carrier of the trait, your child will not have sickle cell disease. However, you have a 50% chance of having a child with the trait. The good news is that people with the sickle cell trait usually have very few (or no) medical problems.
None but... If you do not have sickle trait your children cannot have sickle cell anemia. However, if you carry a gene for other abnormal hemoglobins (like hemoglobin c) your child could be born with sc disease. If you have beta-thalassemia minor, there is a 1/4 chance your child could have sickle-thalassemia, that can cause health problems also. So, you need to know a little more about your blood to be sure.
Carrier vs. Affected. Sickle cell trait denotes being a carrier while sickle cell disease is someone who has the disorder. Sickling requires 2 genes. A person with the s gene and a normal gene would be a carrier and considered to have sickle cell trait. Someone who has s and s would be considered to have sickle cell disease and would likley be affected.
No. It is always a good idea to get up and walk around a little bit on long flights, as the flights themselves increase the risk of getting a clot in the legs (lower extremities). However the sickle cell trait does not place you at any higher of a risk for a venous clot than the general population.
Probably Not. Traveling on a pressurized commercial airplane shouldn't pose anyproblems if you truly are carrying the trait (hb a/s) and not a variant (hb s/c) which has been associated with sickling in prolonged air trips although not (hb s/s). You need to have a hemoglobin electrophoresis as one way to diagnose these variants. Prevention is with supplemental o2 in flight.
Not necessarily. If you and your partner both have sickle cell trait, there is a 25% chance your child will be normal (not have sickle cell trait or anemia), a 50% chance they will have sickle cell trait (just like you and your partner), and a 25% chance they will have sickle cell disease. Prenatal diagnosis is available early in pregnancy that will tell you what your child has.