5 doctors weighed in:

Can you have partial sickle cell disease?

5 doctors weighed in
Dr. Shabbir Hossain
Internal Medicine
2 doctors agree

In brief: Sickle cell trait

If you only have 1 of the two genes for sickle cell disease, you have sickle cell trait.
This is a benign finding with no real symptoms. It's main significance is that you can pass this gene on to your children. If your partner also has sickle cell trait, then there is a probability that a child in the next gen will have sickle cell disease.

In brief: Sickle cell trait

If you only have 1 of the two genes for sickle cell disease, you have sickle cell trait.
This is a benign finding with no real symptoms. It's main significance is that you can pass this gene on to your children. If your partner also has sickle cell trait, then there is a probability that a child in the next gen will have sickle cell disease.
Dr. Shabbir Hossain
Dr. Shabbir Hossain
Thank
Dr. Scott Diede
Pediatrics - Hematology & Oncology
1 doctor agrees

In brief: Yes.

A person with sickle cell disease normally has two copies of the sickle cell mutation in each of their beta-hemoglobin genes (hb ss).
Those with sickle trait have one unaffected copy and one sickle (hb as, where "a" is normal). Other variants of beta-hemoglobin can be inherited along with one copy of the sickle gene (hb sc, sd, se, or s/beta-thal). These can give less severe disease than hb ss.

In brief: Yes.

A person with sickle cell disease normally has two copies of the sickle cell mutation in each of their beta-hemoglobin genes (hb ss).
Those with sickle trait have one unaffected copy and one sickle (hb as, where "a" is normal). Other variants of beta-hemoglobin can be inherited along with one copy of the sickle gene (hb sc, sd, se, or s/beta-thal). These can give less severe disease than hb ss.
Dr. Scott Diede
Dr. Scott Diede
Thank
Get help from a real doctor now
Dr. Peter Kurzweil
Board Certified, Internal Medicine
46 years in practice
16M people helped
Continue
108,000 doctors available
Read more answers from doctors