7 doctors weighed in:
How long can you take tylenol (acetaminophen) pm (i.E. How many consecutive nights) for it to remain effective and safe?
7 doctors weighed in

Dr. Donald Jacobson
Psychiatry
2 doctors agree
In brief: Efficacy not good
In spite of the fact that it seems that many people are able take Benadryl for days on end and it still works, i really don't see any necessity of adding in the tylenol (acetaminophen).
And studies on Benadryl alone, most people lose its efficacy in lab studies after about three days of use. Then they have to wait several days before it will actually work again. Add to that the impairment of driving in the morning that has been documented in studies and the potential for weight gain and Benadryl and you really do not have a very ideal sleep medication there.

In brief: Efficacy not good
In spite of the fact that it seems that many people are able take Benadryl for days on end and it still works, i really don't see any necessity of adding in the tylenol (acetaminophen).
And studies on Benadryl alone, most people lose its efficacy in lab studies after about three days of use. Then they have to wait several days before it will actually work again. Add to that the impairment of driving in the morning that has been documented in studies and the potential for weight gain and Benadryl and you really do not have a very ideal sleep medication there.
Dr. Donald Jacobson
Dr. Donald Jacobson
Thank
Dr. Clifford Gevirtz
Anesthesiology
2 doctors agree
In brief: Very safe
The Benadryl in the tylenol (acetaminophen) pm is what makes you sleepy.
It is non habit forming so it is safe to take for a week without a problem, i would not suggest taking it for months at a time and don't drink alcohol with tylenol (acetaminophen) as it can hurt your liver. You should also consider no caffeine for 8 hours before bed. Slighter cooler temp in your bedroom. No vigorous exercise for 4 hours before bed.

In brief: Very safe
The Benadryl in the tylenol (acetaminophen) pm is what makes you sleepy.
It is non habit forming so it is safe to take for a week without a problem, i would not suggest taking it for months at a time and don't drink alcohol with tylenol (acetaminophen) as it can hurt your liver. You should also consider no caffeine for 8 hours before bed. Slighter cooler temp in your bedroom. No vigorous exercise for 4 hours before bed.
Dr. Clifford Gevirtz
Dr. Clifford Gevirtz
Thank
Dr. Luis Villaplana
Internal Medicine
1 doctor agrees
In brief: It stops working
Everybody is different but i bet you if you are taking it daily, probably within 3-8 weeks it won't do the same for you.

In brief: It stops working
Everybody is different but i bet you if you are taking it daily, probably within 3-8 weeks it won't do the same for you.
Dr. Luis Villaplana
Dr. Luis Villaplana
Thank
Get help from a real doctor now
Dr. Steven Seres
Board Certified, Internal Medicine
17 years in practice
497K people helped
Continue
108,000 doctors available
Read more answers from doctors