7 doctors weighed in:
Do antidepressants cause restless leg syndrome?
7 doctors weighed in

Emily Lu
Family Medicine
5 doctors agree
In brief: Sometimes
Akisthesia (an inner restlessness that can manifest very much like restless legs syndrome) has been reported as a side effect of some antidepressants like prozac, Paxil (paroxetine) and tricyclic antidepressants.
However, it is more commonly seen in patients that are on antipsychotic drugs like haldol.

In brief: Sometimes
Akisthesia (an inner restlessness that can manifest very much like restless legs syndrome) has been reported as a side effect of some antidepressants like prozac, Paxil (paroxetine) and tricyclic antidepressants.
However, it is more commonly seen in patients that are on antipsychotic drugs like haldol.
Emily Lu
Emily Lu
Answer assisted by Emily Lu, Medical Student
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1 comment
Dr. Donald Hazlett
Even the newer atypical antipsychotic/mood stabilizing medications can cause akathisia much more commonly than serotonergic/tricyclic antidepressants but less so than the older typical antipsychotics.
Dr. Aaron Milstone
Internal Medicine - Pulmonology
In brief: Yes
Antidepressants among the ssri class (zoloft, paxil, (paroxetine) etc) can cause restless legs syndrome.
Other causes include anemia, pregnancy, alcohol use and others.

In brief: Yes
Antidepressants among the ssri class (zoloft, paxil, (paroxetine) etc) can cause restless legs syndrome.
Other causes include anemia, pregnancy, alcohol use and others.
Dr. Aaron Milstone
Dr. Aaron Milstone
Thank
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