I took Excedrin with aspirin but my eyes swelled, what does it means

Possibly . It might mean that you're allergic to aspirin. Have you ever taken Aspirin before? Did you get itchy? Did you get a rash? What were you taking the excedrin for in the first place? Your family doctor can help you sort through these issues. It's important because if you have Aspirin allergy, which is not rare, you need to know it!