What are the side effects of lupron (leuprolide) depot?

Side effects. Lupron (leuprolide) side effects are hot flashes and head aches. If taken for longer than 6 months some reversible bone loss can be found with bone scans.
Hot flashes. Depo-lupron puts you in a temporary menopausal state. Many women experience hot flashes, night sweats and vaginal dryness. You may also have an episode of vaginal bleeding 1-2 weeks after administration. It can only be used for a short period of time as it will affect bone health if used for extended periods of time.