10 doctors weighed in:

How well does clomiphene usually work?

10 doctors weighed in
Dr. Jessica Scotchie
Obstetrics & Gynecology
5 doctors agree

In brief: Depend on indication

For ovulation (when a patient who doesn't release an egg on her own), then assuming there are open tubes and normal sperm, Clomid (clomiphene) restores normal monthly conception rates: about 20%/month for women < 35, 10%/month for women > 35.
When used for unexplained infertility, then it is less effective, generally about 5-7%/month depending on whether or not IUI is also used.

In brief: Depend on indication

For ovulation (when a patient who doesn't release an egg on her own), then assuming there are open tubes and normal sperm, Clomid (clomiphene) restores normal monthly conception rates: about 20%/month for women < 35, 10%/month for women > 35.
When used for unexplained infertility, then it is less effective, generally about 5-7%/month depending on whether or not IUI is also used.
Dr. Jessica Scotchie
Dr. Jessica Scotchie
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Dr. Mark Perloe
Fertility Medicine
3 doctors agree

In brief: Ovulate or Pregnant

While up to 80% will ultimately ovulate with clomiphene, only about half of those will conceive.
Before using clomid, a sperm test is needed. Consider an hsg as well. Three months at most before considering other options. Many form large cysts with clomid, so an ultrasound is helpful at the start of each treatment cycle.

In brief: Ovulate or Pregnant

While up to 80% will ultimately ovulate with clomiphene, only about half of those will conceive.
Before using clomid, a sperm test is needed. Consider an hsg as well. Three months at most before considering other options. Many form large cysts with clomid, so an ultrasound is helpful at the start of each treatment cycle.
Dr. Mark Perloe
Dr. Mark Perloe
Thank
Dr. Victor Beshay
Fertility Medicine
3 doctors agree

In brief: Estrogen receptors

Clomiphene is believed to block the estrogen receptor in the brain.
The brain in turn produces hormones that stimulate the ovaries to produce eggs.

In brief: Estrogen receptors

Clomiphene is believed to block the estrogen receptor in the brain.
The brain in turn produces hormones that stimulate the ovaries to produce eggs.
Dr. Victor Beshay
Dr. Victor Beshay
Thank
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