Is it possible to get cancer from using fluorouracil cream?

Very very unlikely. Fluorouracil is a type of chemotherapy, and it works by interfering with dna reproduction. So yes, there is a very tiny chance that it could cause a mutation that would lead to cancer. However, the cream is used on the skin, and very little should be absorbed. The chance that you would get a cancer from it is miniscule. We give the same drug intravenously and by mouth at much higher doses!