4 doctors weighed in:

Why do lupus tests sometimes come back negative?

4 doctors weighed in
Dr. Morris Westfried
Dermatology
2 doctors agree

In brief: Not 100 %

There re several tests for lupus ana, double stranded dna and none of these tests is 100 per cent reliable for the diagnosis of lupus.
A similar situation occurs in rheumatoid arthritis where there seedless negatives as well as false positives. If there is akin involvement a skin biopsy for direct exam as well as immunoflourescence can help with diagnosis.

In brief: Not 100 %

There re several tests for lupus ana, double stranded dna and none of these tests is 100 per cent reliable for the diagnosis of lupus.
A similar situation occurs in rheumatoid arthritis where there seedless negatives as well as false positives. If there is akin involvement a skin biopsy for direct exam as well as immunoflourescence can help with diagnosis.
Dr. Morris Westfried
Dr. Morris Westfried
Thank
Dr. John Goldman
Internal Medicine - Rheumatology

In brief: Depends

Which tests are you thinking of? Certain tests can improve because you have a chance that the lupus activity is down.
Sometime tests are negative because of laboratory error. Sometimes blood tests are negative because you have also developed certain blocking substances that can interfere with the test. This all depends on your status, lupus activity, immunologic responses, etc.

In brief: Depends

Which tests are you thinking of? Certain tests can improve because you have a chance that the lupus activity is down.
Sometime tests are negative because of laboratory error. Sometimes blood tests are negative because you have also developed certain blocking substances that can interfere with the test. This all depends on your status, lupus activity, immunologic responses, etc.
Dr. John Goldman
Dr. John Goldman
Thank
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