8 doctors weighed in:

Can systemic inflammatory response syndrome in a 5 year old with juvenile rheumatoid arthritis cause macrophage activation syndrome?

8 doctors weighed in
Dr. Alan Solinger
Internal Medicine - Rheumatology
1 doctor agrees

In brief: Cause - no

Mas has sirs as part of its clinical features.
Sirs is just a description of some signs and symptoms of excessive inflammatory mediator release that is found as part of several clinical syndromes. Discuss this with your pediatric rheumatologist.

In brief: Cause - no

Mas has sirs as part of its clinical features.
Sirs is just a description of some signs and symptoms of excessive inflammatory mediator release that is found as part of several clinical syndromes. Discuss this with your pediatric rheumatologist.
Dr. Alan Solinger
Dr. Alan Solinger
Thank
Dr. Robert Lowe
Pediatric Rheumatology

In brief: Yes but it depends

Children with systemic-onset jra can definitely get mas which may be triggered by a flare of disease or an infection such as mononucleosis.
Kids with mas can become extremely ill; mas can be life-threatening. A ferritin level should be checked and if it is very high or the child looks very ill, they should be evaluated in a children's hospital where a board certified pediatric rheumatologist works.

In brief: Yes but it depends

Children with systemic-onset jra can definitely get mas which may be triggered by a flare of disease or an infection such as mononucleosis.
Kids with mas can become extremely ill; mas can be life-threatening. A ferritin level should be checked and if it is very high or the child looks very ill, they should be evaluated in a children's hospital where a board certified pediatric rheumatologist works.
Dr. Robert Lowe
Dr. Robert Lowe
Thank
Dr. Jay Park
Pediatrics

In brief: Not exactly

Macrophage activation syndrome has been observed in children with systemic onset jra.
Macrophages are activated to engulf various blood cells resulting in low hemoglobin, platelet, and fibrinogen level.

In brief: Not exactly

Macrophage activation syndrome has been observed in children with systemic onset jra.
Macrophages are activated to engulf various blood cells resulting in low hemoglobin, platelet, and fibrinogen level.
Dr. Jay Park
Dr. Jay Park
Thank
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