Is neurogenic bladder a side effect of bortizomib in the treatment of of multiple myeloma?

Possible. Bortezomib, the proteosome inhibitor is licensed for use in multiple myeloma. It has also been used to treat antibody mediated transplant rejection. One side effect is peripheral neruopathy--about 10% of patients. One can speculate that the same mechanism can cause either a failure to emtpy or some urgency of urination. You would need a formal urodynamic assessment to determine this.

Related Questions

What are the side-effects of velcade (bortezomib) in the treatment of multiple myeloma?

Minimal. It us a fairly well tolerated drug. Its main side effect is neuropathy which can menifest as tingling, numbness of the toes and fingers and lead to weakness in the hands if the drug is continued for long time. But it does recover after stopping or change over to once weekly use. Read more...

The doctor prescribed melpalan, velcade (bortezomib) and dexamethasone for 78 yrs old male with multiple myeloma. He later increase the dose of melphalan from 10 mg to 14 mg despite the treatment progress. Is this warranted considering high AST and alt?

Speak with physician. The best advice at this point is to speak with the treating physician and ask for an explanation regarding the increase in the medication given the progression of disease on the current treatment. If you are not satisfied with the explanation then by all means seek a second opinion consultation. At times, changes in regimens are easily explained; don't be afraid to ask. Read more...

Is it necessary to take dexa along with Velcade (bortezomib) same day for multiple myeloma patient of 80 yrs as acute diarrhea is encountered after every dose?

See below. Velcade may produce diarrhea, but DEX usually not. Velcade and DEX have been given same day only for the convenience, and I see no reason to try to give them on separate days. Alternatively, one can reduce the dose of Velcade or try anti-diarrhea agent prophylactively, such as imodium (loperamide). Diarrhea needs to be treated with antidiarrhea agents and electrolytes monitoring. Read more...

What types of treatment exist for multiple myeloma and other plasma cell cancer types?

"Many" Myeloma and other plasma cell dyscrasia treatments has evolved from standard cytotoxic approaches (eg mp, vad, hypercvad) to "novel" therapies. Immunomodulatory drugs (imids) - eg thalidomide, lenalolidomide, pomalidomide proteasome inhibitors - eg, bortezomib, carfilzomib, etc other: hsp90 inhibitors, hdaci, b-raf, etc. Over the last few years multiple new drugs have been approved for myeloma. Read more...
Multiple options. There are a variety of options for treating multiple myeloma. The main therapy is chemotherapy but radiation treatments are sometimes used for localized areas. Also a stem cell transplant is often part of the treatment. Chemotherapy or a stem cell transplant are used for a related plasma cell problem called 'primary systemic al amyloidosis.'. Read more...

What types of questions should I ask my doctor regarding treatment for multiple myeloma or other plasma cell cancer?

1-2-3. Cancer 1-2-3: 1) diagnosis - myeloma vs. ? 2a) stage - iss (not that relevant for individual) 2b) prognostic factors - eg cytogenetics, pcli (if avail), gep (new), bone disease, etc. 3) treatment -- goals (response or quality or....) and options. Some regiments are easy eg rd which is good for a low burden mm disease and working pt vs. More complicated "induction" regimen for high risk/burden. Read more...
Www.cancer.net. Please check out www.cancer.net for an excellent patient resource, including questions to ask your physicians. http://www.cancer.net/cancer-types/multiple-myeloma. Read more...

If I need treatment now, what are my options for multiple myeloma and how successful are they likely to be?

It depends... Treatment options for mm are plentiful and are dependent on: patient characteristics (age, comorbidities -- diabetes, neuropathy, cv disease, etc), mm cytogenetics (risk), disease burden, etc. Treatment options need to be customized to the individual patient -- more so than in the past because of rapid developments in mm. That is good news. Read more...
It depends... An international team has put together guidelines on when patients with myeloma should be treated. Your cancer doctor should be aware of them. There are many things now which can predict how well you will do with treatment and what type of treatment you should have. Patients live much longer with this disease than a decade ago..Some over 20 years making this a chronic illness in many ways. Read more...

Has tinospora ever been used to treat multiple myeloma or be used at the same time as other multiple myeloma treatment?

Maybe no data? Never heard of tinospora until your question. I saw a scattering of mentions on an internet search, but no real data. A recent august 2011 review on tinospora in various conditions (not myeloma) is here: http://www.Lahey.Org/departments_and_locations/departments/cancer_center/ebsco_content/multiple_myeloma.Aspx?Chunkiid=111811. Read more...