Can a fibroid and a cyst come up on a ca 125 test?

Yes. Fibroids, benign cysts, endometriomas, and endometriosis can all result in a positive ca-125 test. Ca-125 is not a good screening test for ovarian cancer because there are so many causes of false positives. And furthermore, 50% of st 1 ovarian cancer may have a negative ca-125. Nonetheless, if you have a positive ca-125 and an ovarian cyst, it will probably need to be explored.