Can doxycycline be used in a lupus (sle) patient that is allergic to penicillin?

Yes. Tetracyclines (e.g. Doxycycline), quinolones (e.g. Ciprofloxacin), macrolides (e.g. Clarithromycin), aminoglycosides (e.g. Gentamicin) and glycopeptides (e.g. Vancomycin) are all unrelated to penicillins and are safe to use in penicillin allergic subjects.

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