Is diphenhydramine hydrochloride and doxylamine succinate ok together?

Caution Required. Both drugs have similar "mechanisms of action." therefore, the effects they produce are "additive" and, in theory, can pile up to create more effects than would be predicted if each drug were taken by itself...Almost as if 1+1=3! both drugs produce sedation and have anti-histamine properties. So, excessive sleepiness or agitation can happen. Be cautious..Speak to your provider or pharmacist!
Not a good idea. Both drugs are antihistamines that depress the central nervous system. Consequently they are often used as sleep aids. Although these are very safe drugs, they have similar effects on the body so taking both may be like taking twice the dose of one. Overdosage can produce side effects that range from minor (dry mouth, excessive sleepiness) to serious (high blood pressure, nausea) to death.

Related Questions

Best sleep aid--diphenhydramine hydrochloride or doxylamine succinate?

Both commonly used. Both of these are commonly used over-the-counter. They are sedating and help people fall and stay asleep to a greater or lesser degree depending on the person. Often tolerance develops if the person takes one or the other regularly. Melatonin is another otc medication that can help with sleep. Be sure to practice sleep hygiene -- structuring your sleep, avoid lying long periods not sleeping, etc. Read more...

What is Benadryl (diphenhydramine) (and also the anti-histamine doxylamine succinate, both sleeping aids)?

Antihistamines. Benadryl (diphenhydramine) and doxylamine are antihistamines. Histamine is a chemical made in the brain which keeps you alert, so antihistamines cause the opposite effects- sedation. But they are not good as long term sleep aids. Besides improving your sleep hygiene, it may be a good idea to see a sleep medicine specialist to get to the bottom of your trouble sleeping. Read more...

Can you tell me about Benadryl (diphenhydramine) (and also the anti-histamine doxylamine succinate, both sleeping aids)?

Moderation. Doxylamine and Diphenhydramine are both available over-the-counter, both have similar anti-histamine properties, used as sleep aids to help cause drowsiness to help with sleep onset. Sleep hygiene techniques are the first step in getting better sleep. Prescription sleep aids are much better supported by evidence as effective for sleep and can be discussed with your physician if needed. Good luck! Read more...