I have arthritis in my knees and have pain at top of left calf on the side, could these be related?

Possibly... Arthritis in any joint can lead to inflammation around the joint too. However, the area you are describing could also be a strained calf muscle. Try to ice and rest the area, but if it does not improve, or if it swells or turns red/hot, see your doctor.
Possibly. Sometimes arthritis in a joint can cause nearby muscles to become irritated. This can also happen on the opposite side from the bad joint, as you begin to favor your good side.