2 doctors weighed in:
What is the difference between the arthritis medicines mobic (meloxicam) and celebrex?
2 doctors weighed in

Dr. Thomas Namey
Internal Medicine - Rheumatology
1 doctor agrees
In brief: Depends.
Celebrex, or celecoxib, las a lower risk of bleeding from the gut, but also is the only NSAID that does not block the effect of low dose Aspirin used to prevent heart disease or stroke.
Meloxicam blocks aspirins effect, as do all other drugs like Naproxen (aleve), and Ibuprofen (motrin). Unfortunately, Celebrex remains on patent and is much more expensive. For most, Meloxicam is a good choice.

In brief: Depends.
Celebrex, or celecoxib, las a lower risk of bleeding from the gut, but also is the only NSAID that does not block the effect of low dose Aspirin used to prevent heart disease or stroke.
Meloxicam blocks aspirins effect, as do all other drugs like Naproxen (aleve), and Ibuprofen (motrin). Unfortunately, Celebrex remains on patent and is much more expensive. For most, Meloxicam is a good choice.
Dr. Thomas Namey
Dr. Thomas Namey
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2 comments
Dr. Bruce Rothschild
Mobic at 7.5 mg/day may be as safe as Celebrex, but that GI safety is lost at 15 mg/day
Dr. Thomas Namey
I agrree, but did not mention salsalate, or Mg-choline-trisalicylate
Dr. Bruce Rothschild
Internal Medicine - Rheumatology
In brief: Safety
Both are anti-inflammatory, but Celebrex blocks a specific enzyme called cox-2 at any dose, while Mobic (meloxicam) is nonspecific above 7.
5 mg/day. The extrac GI safety of blocking the specific enzyme is lost at doses of Mobic (meloxicam) above 7.5 mg.

In brief: Safety
Both are anti-inflammatory, but Celebrex blocks a specific enzyme called cox-2 at any dose, while Mobic (meloxicam) is nonspecific above 7.
5 mg/day. The extrac GI safety of blocking the specific enzyme is lost at doses of Mobic (meloxicam) above 7.5 mg.
Dr. Bruce Rothschild
Dr. Bruce Rothschild
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