5 doctors weighed in:
Can I use methotrexate to treat psoriatic arthritis when I also have gallbladder stones and severe attacks?
5 doctors weighed in

Dr. Barry Rosen
Surgery
2 doctors agree
In brief: Yes, but...
...Why are you enduring the pain and risk of frequent gallbladder attacks? In the modern era of minimally invasive surgery, the risks are often greater to continue to have gallbladder attacks rather than the risk of surgery.
Have you spoken with your primary care physician or rheumatologist about these attacks?

In brief: Yes, but...
...Why are you enduring the pain and risk of frequent gallbladder attacks? In the modern era of minimally invasive surgery, the risks are often greater to continue to have gallbladder attacks rather than the risk of surgery.
Have you spoken with your primary care physician or rheumatologist about these attacks?
Dr. Barry Rosen
Dr. Barry Rosen
Thank
1 comment
Dr. Michael Zadeh
Agree with Dr. Rosen. The frequency of having subsequent gallbladder attacks increases with each attack and can lead to complications such as inflammation of the liver and pancreas which can be fatal.
Dr. Thomas Namey
Internal Medicine - Rheumatology
In brief: Yes you can use MTX!
Methotrexate (mtx), is best given by subcutaneous injection, thereby bypassing the liver, which is not if taken orally.
Virtually no liver issues occur if the oral dose is switched to the s.C. Route, in tradional doses of 10-25mg per week.

In brief: Yes you can use MTX!
Methotrexate (mtx), is best given by subcutaneous injection, thereby bypassing the liver, which is not if taken orally.
Virtually no liver issues occur if the oral dose is switched to the s.C. Route, in tradional doses of 10-25mg per week.
Dr. Thomas Namey
Dr. Thomas Namey
Thank
Dr. Angus Worthing
Internal Medicine
In brief: Depends
Ask your doctor(s).
Gallstones are not listed as a side effect of Methotrexate by the us fda, but there are reports of gallstones in people taking Methotrexate so it's theoretically possible that it could worsen your problem. A low dose may be reasonable. There are also other treatments for psoriatic arthritis. Your doctor(s) can give you the best individualized advice about this complex question.

In brief: Depends
Ask your doctor(s).
Gallstones are not listed as a side effect of Methotrexate by the us fda, but there are reports of gallstones in people taking Methotrexate so it's theoretically possible that it could worsen your problem. A low dose may be reasonable. There are also other treatments for psoriatic arthritis. Your doctor(s) can give you the best individualized advice about this complex question.
Dr. Angus Worthing
Dr. Angus Worthing
Thank
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