9 doctors weighed in:
How many mg of diphenhydramine is equal to a 10 mg ambien (zolpidem)?
9 doctors weighed in

Dr. Mark Reynolds
Psychiatry
8 doctors agree
In brief: Not equivalent
Diphenhydramine is an antihistamine that causes drowsiness by blocking histamine receptors.
Usual doses are 25-50 mg. Ambien (zolpidem) is what is called a non benzodiazepine hypnotic, it cause drowsiness by binding to the Alpha subunit of the benzodiazepine receptor. Usual dosing is 5-10 mg. As their mechanism of action is completely different, there is no dose equivalency.

In brief: Not equivalent
Diphenhydramine is an antihistamine that causes drowsiness by blocking histamine receptors.
Usual doses are 25-50 mg. Ambien (zolpidem) is what is called a non benzodiazepine hypnotic, it cause drowsiness by binding to the Alpha subunit of the benzodiazepine receptor. Usual dosing is 5-10 mg. As their mechanism of action is completely different, there is no dose equivalency.
Dr. Mark Reynolds
Dr. Mark Reynolds
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