Not necessarily. If you and your partner both have sickle cell trait, there is a 25% chance your child will be normal (not have sickle cell trait or anemia), a 50% chance they will have sickle cell trait (just like you and your partner), and a 25% chance they will have sickle cell disease. Prenatal diagnosis is available early in pregnancy that will tell you what your child has.
No. If you and your partner carry the gene for sickle cell disease then there is a 25% chance that the baby will have the disease.
Genetic test Sickle. Yes the test is done on high risk women at the 17 week of gestation by doing amniocentesis with the permission of both patents.
Sickle. What is the rate of occurrence for the disease sickle cell anemia or disease? " -- the occurrence rate is 25% if both parents are carriers, 50% if one parent has it and another parent is a carrier and 100% if both parents have it. Roughly 1, 000 infants are born, in the U.S., with it each year.
Depends on geography. Given the single base change responsible for sickle cell trait in the beta globin gene, the frequency of new mutations is essentially zero. According to the cdc in the usa, 8-10% of african americans have sickle cell trait and 0.2% have sickle cell disease. Conversely, in western africa, the prevalence of sickle cell trait is 30-40%.
Blood. The genetic defect is in the hemoglobin molecule.
I Don't Think So. I'm guessing a bit as to what you mean by your question. Sickle cell anemia is caused by a gene mutation on both copies of the beta globin gene. In that sense it is a genetic disease. However, a number of other factors, some of them environmental, can influence the type and severity of problems that patients with ssa have.
Hemoglobinopathy. Patients with sickle cell anemia make an abnormal hemoglobin (hgb.). Normal HGB consists of paired protein chains (globin) and an iron containing part (heme). Patients with ssa inherit an abnormal beta-globin gene from each parent. Carriers have one normal beta-globin gene and one sickle beta globin gene. The carriers (trait) have no symptoms.
Important gene... Sickle cell anemia is caused by a mutation in the gene that tells your body to make hemoglobin. Hemoglobin allows red blood cells to carry oxygen from your lungs to all parts of your body. In sickle cell anemia, the abnormal hemoglobin causes red blood cells to become rigid, sticky and misshapen. These abnormal red blood cells lead to the various symptoms of the disease.
Abnormal protein. One genetic mutation such as the one that is found in sickle cell causes abnormal hemoglobin beta chains to form which result in sickling of the hemoglobin since it can't go to its normal shape. The sickling of the hemoglobin and red blood cell gets caught in small vessels leading to all of the problems associated with sickle cell disease.