Which disease causes white spots on the brain and spine?

Multiple sclerosis. Many diseases can cause "white spots" to appear on the MRI imaging studies of the brain and spine. Multiple sclerosis is one of the most common conditions. Strokes, cancer, infection, and some other rare neurological disorders can also cause similar issues. Sometimes further physical examination, blood work, and a spinal fluid tap may be necessary to get a diagnosis.
Demeylinating ones. There are several types of processes and diseases that can cause this and sometimes they are normal findings-see a neurologist.