I recently starting taking Depakote 250 mg twice a day & Prozac (fluoxetine) 20 mg once daily I hear Depakote causes severe weight gain & weight gain is also a side effect of prozac (fluoxetine). Is this true?

Weight gain. Yes, Depakote can cause weight gain, and some people also gain weight w/prozac. Not all do, though. It will be important to make sure you're exercising regularly, and be wise with your meals -- healthy, whole, nutritious foods and much less in desserts, etc unless you really did exercise that day. The good news is that exercise in itself is a useful treatment for depression! good luck to you.