I have been using nose spray for approximately 45 years 2 or more times a day (like afrin (oxymetazoline) and 4-way) could I get cushing' disease and what other side e?

No. You cannot get cushings' syndrome, the result of taking large amounts of corticosteroids, from decongestant sprays like afrin. You can become and probably are dependent on these sprays, a condition called rhinitis medicamentosa. You also cannot get cushings' from using topical corticosteroid nasal sprays. The dose is just too low to cause such a side-effect.