Is there a correlation between menopausal mood swings and affairs of the heart. My wife of 28 years no longer feels that she can confide in me.?

Trust issues? Confiding in a spouse or partner can be affected by many things, but generally not menopausal mood swings. Any trust issues in your relationship could cause difficulty. Some couples' counseling could be helpful in understanding and working through these things, if both of you are willing. Severe depression w/paranoia is another thought -- but other symptoms of depression would be present also.