4 doctors weighed in:

I take Xanax (alprazolam) and Valium will grapefruit juice have a side effect?

4 doctors weighed in
Dr. Steven Reidbord
Psychiatry
3 doctors agree

In brief: Minor

Grapefruit juice inhibits the liver enzymes that break down certain medicines, resulting in a small increase in the medicine's effect.
This definitely occurs with valium; there is some uncertainly whether it affects xanax (alprazolam) as much, or at all. It takes a lot of grapefruit juice (at least a pint, probably more) to have this effect. Tell your doc if you drink lots of grapefruit juice regularly.

In brief: Minor

Grapefruit juice inhibits the liver enzymes that break down certain medicines, resulting in a small increase in the medicine's effect.
This definitely occurs with valium; there is some uncertainly whether it affects xanax (alprazolam) as much, or at all. It takes a lot of grapefruit juice (at least a pint, probably more) to have this effect. Tell your doc if you drink lots of grapefruit juice regularly.
Dr. Steven Reidbord
Dr. Steven Reidbord
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