I'v had sinus pressre for what seems to be forever. My doc put me on a zpack but I still have my sinus headache. Whats the difference btm sinus and a migrane. I also get headaches at the back of my head where the base and that bone meet. Zpack doesn't

Schedule Appointment. Schedule an appointment with an otolaryngologist.
Decongestant? Zpack (azithromycin) is an antibiotic and does not treat the symptoms of headache- just an underlying infection which may be the cause of the headache. A sinus headache is caused by pressure from congestion in the sinuses. If your blood pressure is fine, a decongestant such as Pseudoephedrine could be taken along with the zpack to relieve the congestion. Ibuprofen can help with pain and inflammati.