How long before/after taking Zoloft (sertraline) can you consume alcohol? I've been takin 100mg at night but like to have a drink with friends every now and then

Ask your doctor. Your own physician knows more than we do about your personal history and use of other medications/drugs and/or alcohol. So you should ask him/her about this question to get a personalized answer. Most psychiatrists would suggest not using alcohol at all while being treated with zoloft (sertraline) and other antidepressants.
Zoloft (sertraline) and alcohol. Its not advisable to take alcohol with the antidepressant , you could also take zoloft (sertraline) in morning. Best to avoid alcohol, the combination can depress the brain.