Could premerin homone replacement cause Paget breast cancer?

Unlikely. We think that combined hormone replacement including estrogen and Progesterone cause an increase in breast cancer of which paget's disease if the breast is a type. Premarin (conjugated estrogens) only contains estrogen.

Related Questions

Is it possible that premerin homone replacement cause Paget breast cancer?

NO Unlikely cause. Paget's disease is a intra-ductal breast cancer where the tumor cells spurts out from lymphatics to nipple areola area , causing nipple bleed ; eczema to the area. Read more...

Does hormone replacement therapy for menopausal symptoms cause breast cancer?

It can. The cause of breast cancer is so complex and poorly understood that it's better to talk about "associations" rather than "causes". Studies have shown that women who have used hormone replacement have a slightly higher incidence of breast cancer as compared to women that have not. In general, if you can avoid it, it's better to, especially if you have other risk factors for breast cancer. Read more...
In short, no. There are three human esrogens: Estradiol (from the ovary), estriol (from the placenta in pregnancy) and estrone (from peripheral fat conversion). Estrone is probably the culprit since women with excess peripheral body fat have increase rates of estrogen related cancers (breast, uterus, ovary, colon). Many oral estrogen hormones on the market are converted to estrone in the liver. Read more...
Increases risk. Hormone replacement therapy (hrt) has been shown to increase one's risk for breast cancer if taken for longer than 5 years. The current recommendation is to take low doses for a limited amount of time and then stop. There are some other non hormonal medications that can be used to help manage menopausal symptoms. Read more...
Depends. Virtually all of the studies showing that hrt increases breast cancer have been done on premarin (conjugated estrogens). Premarin (conjugated estrogens) is converted to estrone in the liver when taken orally. Overweight women convert adrenal hormones into estrone in peripheral body fat & have increased rates of estrogen dependent cancers (breast, colon, uterine). I suspect the culprit is estrone, not estradiol/estriol, the other human estrogens. Read more...

, ovarion or breast cancer dies not run in my family. May I safely continue hormone replacement.

Yes. As a neurologist, I am bias towards HRT because of known risk of dementia. I am sure oncologist would beg to differ with me since they are biased towards their profession. Very little to suggest if any that if there is no familly history, that HRT puts you at risk for cancer. Read more...
Be careful. At your age, the risk with hormone therapy increases. You need to be careful. When treating with hormones, you want to use the smallest dose possible and treat for the shortest time possible. It is very important that you meet with your physician to discuss your risks and consider checking genetic studies, and hormone levels. Make sure you are screening for breast disease as well. Be careful! Read more...

Does hormone replacement therapy increase your chances for breast cancer expotentionally?

Not exponentially. Data from the whi (women's health initiative) study show that estrogen alone does not significantly increase the risk of breast cancer, especially if started within 5 years of menopause. However, estrogen + Progesterone (needed when women still have a uterus to prevent uterine cancer) increases the risk of breast cancer to about 2x the baseline risk. Progesterone appears to be the "bad guy". Read more...
No. But long-term exposure is probably assocaited with a greater risk of breast cancer. But the actual risk is hard to prove and is certainly not exponential. Still, best not to take ert for more than 5 years unless you are very sympomatic from menopausal symptoms. Read more...
Absolutely Not. The whi as now reviewed was a very poor study overall and likely answers few clinical questions. I agree with the former answer that the progestin component was implicated but would not implicate Progesterone specifically. It was provera, (medroxyprogesterone) a synthetic Progesterone used in the study. The study population does not represent the typical patient we see. You need a consultation with hormone dr. Read more...

How safe is hormone replacement therapy if family history breast cancer?

Short term safety. There is no apparent increased risk for short term use of hormone therapy, with or without a family history. For longer term use (greater than 4 years) it is not clear exactly how the different estrogen and Progesterone formulations and combinations affect risk. Read more...
Varies. If a first order relative (mother, sister, daughter) has bc i would take ert only briefly and then only for severe symptoms. Remember that we try to prevent breast cancer by prescribing tamoxifen - which blocks estrogen. Adding ert definitely increases risk, somewhat, so you have to balance risks/benefits. Some women are miserable without it - and a short course may be appropriate for them. Read more...

Hormone replacement therapy. Estrogen alone increases risk of uterine cancer. Adding progesterone increases risk of breast cancer, but reduces risk of uterine cancer. What's the right balance?

Individual. Yes, estrogen alone does increase the risk of uterine cancer over time. And yes the whi showed that the combination of a certain synthetic estrogen and a certain synthetic progestin increased the risk of breast cancer. But most specialists do not use those older types of synthetic hormones and with newer medications the risks are lower and different. So a balance can be achieved. Read more...

What are symptoms of paget's diease (breast cancer)?

Biopsy. Paget's disease is a rare form of breast cancer. There can be changes on the nipple/areola: discoloration, itching, thickening of the skin, redness, crusting, inversion of nipple. It is diagnosed after obtaining a biopsy of the area on the nipple or areola. In many cases, there are no abnormalities seen on mammogram or ultrasound. Paget's has a good prognosis if diagnosed early. Read more...
Skin irritation... Paget disease often shows up as a skin irritation in and around the nipple and areola area. Most women experience itching and redness of the skin and some degree of oozing and crusting of the skin which is often mistaken for a benign skin condition. But a biopsy often reveals cancer cells in the skin and often a hidden lump is fiound in the breast, which is cancerous. Read more...