How can you relieve eyes that are itchy and puffy due to acne cream?

Avoidance. When applying acne cream, avoid applying near/around the eyes, and applying sparingly. Most acne creams only require a pea-sized amount of product for a face application, which is applied by dabbing (on cheeks, chin, forehead, & nose) then rubbing in. If your symptoms occur or worsen despite proper application, stop using the product & see your physician as you may be having an allergic reaction.
Avoid the cream . Please do not use it around the eye, it is causing you eye allergy.