Why does my wife wheeze after having wine?

Could be... ...Sensitivity to sulphites in wine, reflux-induced wheezing (alcohol worsens heartburn), or an allergy to a wine component.
Grape allergy/Asian. It's possible to have allergic reactions from drinking wine. The alcohol is not typically the reason for these reactions. Grapes in wine may be the cause. in asian people, a deficiency of the enzyme, aldehyde dehydrogenase, can result in flushing with some wheezing, after drinking alcohol.