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I was diagnosed with pls. I do have muscle atrophy in both legs. Whats the diff between upper motor neuron dominant ALS and pls?

3 doctors weighed in
Dr. Geoffrey Rutledge
Internal Medicine
2 doctors agree

In brief: PLS versus ALS

Primary lateral sclerosis (pls) is a rare cause of spasticity without muscle atrophy ( no loss of spinal motor neurons).
Extensive atrophy should not occur with pls, but reduced activity by itself can cause some atrophy. Als involves both upper motor neurons (causing spasticity) and lower motor neurons, causing atrophy. Pls has little effect on life span, hereditary spastic paraparesis can mimic.

In brief: PLS versus ALS

Primary lateral sclerosis (pls) is a rare cause of spasticity without muscle atrophy ( no loss of spinal motor neurons).
Extensive atrophy should not occur with pls, but reduced activity by itself can cause some atrophy. Als involves both upper motor neurons (causing spasticity) and lower motor neurons, causing atrophy. Pls has little effect on life span, hereditary spastic paraparesis can mimic.
Dr. Geoffrey Rutledge
Dr. Geoffrey Rutledge
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