Which treatment for osteomyelitis of a patient with sickle cell disease and the osteomyelitis is caused by salmonella?
Ask infectious Disea. Osteomyelitis usually require antibiotics for 6 weeks preferable intravenously because the poor penetration of most antibiotics to the bone. The best answer is given by an infectious disease specialist.
BONE BIOPSY. A surgeon should get a bone biopsy and culture. The results will provide the answer as to which antibiotic is best. Surgical removal of the osteomyelitic bone may also be needed. Dr. Latva.
Surgery. Osteomyelitis is a grave problem. You need proper evaluation for the correct treatment indication. Normally surgery is one of the tools we have in association with IV antibiotics.
Why is there an increased risk of developing osteomyelitis in sickle cell anaemia patients having salmonella infection only? (pathogenesis)
Serum deficiency. Sickle cell patients have an abnormal red blood cell shape. Long bones, particularly at the epiphyseal plates in children, are most vulnerable due to the presence of blood vessels. Combine that with a serum deficiency, against salmonella, it increases the risk of osteomyelitis. Reference article - http://www. Ncbi. Nlm. Nih. Gov/pmc/articles/pmc1541118/.
Not just salmonella. The most common cause of osteomyelitis in patients with sickle cell disease is actually staphylococcus, not salmonella. Sickle patients develop areas of bone infarction which would be generally a setup for any infection.
Sickle cell disease. Although salmonella frequently cause osteomyelitis in sickle cell dz patients, it isn't the most common cause - the most common cause remains staphylococcus. Sickle cell dz predisposes to infections including osteomyelitis due to: hyposplenism & infarcted bone (due to microvascular occlusion). Salmonella is thought to spread from intestine secondary to microinfarction of bowel caused by sickling.
Sickle crisis. The disorder leads to internal clotting during hypoxic states. Any where that happens the organ is damaged. So it is with the circulation in the bones.
Answered previously. Hi anandk6. I answered this question recently. Can you not find the answer or did I not answer it satisfactorily?
Bone infarcts. In sickle cell anemia, there may be bone death, or infarction, with a crisis. These infarctions render bones prone to infections, or osteomyelitis. These infections are most common in long bones, rather than the jaw, but may occur in any bone.
Lack of oxygen. Sickle cell disease can cause tissues to receive inadequate oxygen to survive, most frequently by these red blood cells blocking the blood flow (and hence oxygen) in small blood vessels supplying tissues. If tissue dies it is prone to become infected, and the bodies means of fighting infection is also compromised by the poor blood flow. Large joints are most common, but any tissue is at risk.
Many. Treatments for sickle cell disease include hydroxyurea, blood transfusions, or even bone marrow transplants in certain cases. It depends on the severity of disease. Treating pain crises is also a very important part of managing the side effects of the disease. Because sickle cell disease can affect many organs in the body, it is essential to receive care from an expert in sickle cell disease.
See below. Treatment for sickle cell anemia is usually aimed at avoiding crises, relieving symptoms and preventing complications. If you have sickle cell anemia, you'll need to make regular visits to your md to check your red cell count and monitor your health. Treatments may include medications to reduce pain and prevent complications, blood transfusions and supplemental oxygen, and bone marrow transplant.
Consider hormone-IUD. The best option for you is the one that best meets your needs! Protection against pregnancy, convenience and minimal risk of blood clots are what you should consider. Favorite options include an iud like Mirena (levonorgestrel) or other progestin only containing method. Find a gyn who is comfortable offering treatments for higher risk patients.