Does mthfr heterozygous c677t mutation affect pregnancy?

Likely not much. The existing evidence does not support any strong connection between heterozygotes for either the c or a mutations of mthfr and poor pregnancy outcomes. Homozygotes may well be at greater risk. Depending on clinical history, different levels or surveillance and possible intervention can be considered.
No. It really should not. In fact that is really an old test which is not really tested for very often. It affects a hormone pathway and homocysteine is something that can build up. So mthfr really is not very useful. And being heterozygous is almost never harmful.
No. Screening everybody for polymorphisms at this locus has been promoted by a big-money lab. The test is pricey and not standard, but lawyer-shy physicians may feel they need to test everybody. A majority of women are told they have a health problem. I believe this is unfortunate and that real mthfr disease is extremely rare.

Related Questions

At which temperature (bodily and external) the MTHFR enzyme, a result of heterozygous C677T mutation, becomes thermolabile, i.e.inactive? Thank you.

MTHFR temperature. Interesting question - the best answer I found was MTHFR with either a C677T or A1298 mutation becomes heat labile at temperatures greater than 37 C. Thus as the temperature goes above this - homocysteine starts to accumulate due to lack of enzyme activity . Hope this helps. Read more...
>37 Degrees C. Over 37 degrees, http://www.machaondiagnostics.com/education/display.asp?id=14&type=d. Read more...
N/A. The mutation which causes dysfunction of the MTHFR enzyme is genetic - it doesn't happen because of a variation in body temperature. The rare disorder that this causes is characterized by a possibility of inappropriate clot formation, which can result in stroke or heart attack. However, a person proven to have this mutation may never actually experience such a thrombotic event. . Read more...

My MTHFR gene mutation test says 'not detected' but the note below it says 'this assay detects the mutation C677T in MTHFR'. Does it mean I have it?

MTHFR mutations. MTHFR is the gene which produces methylenetetrahydrofolate reductase. Over 50 known mutations in this gene cause reduced function of the enzyme. The most common mutation causing homocystinuria is the C677T mutation, which among other problems increases the risk of stroke. I can't tell how many mutations your particular test could detect, but you do not have the C677T mutation. Read more...

I am hetero for the mthfr genetic mutation c677t. Everything I've read says I should be gluten/folic acid/dairy free. Advice regarding this mutation?

Spectracell lab. In tx has a test for this. Since you are pos. For it, you can visit their site for info or call them. Peace and good health. Read more...
I can't agree. ~1 person in 4 is like you. The pathology community is divided over MTHFR testing. I'm undecided. A majority of people who take the test will be told they have an 'abnormal' result and are therefore in need of special supplements which they may then be offered by the folks who have done the test. Talk with your own physician and if necessary an authentic genetic counsellor. . Read more...
Not so extreme but.. This is common, affecting up to 50% of people,but the homozygous mutation is much more significant than hetero.Those with it have increased risk of depression, anxiety,cardiovascular disease etc. but it's just one of thousands of genes. My best advice is get a fasting homocysteine test; if 10 or higher take a multivit. with the L-5MTHF form of folate. See https://tinyurl.com/yacd86e4 and comment: Read more...

I have mthfr c677t homozygous mutation, history of rectal cancer ([email protected]). Are these related? What is the serum folate (folic acid) level I should aim if want pregnant?

Not related. These are not related. Also recent data shows no clinical significance of having a mrhfr mutation. It is safe for pregnancy and there is no increase risk for miscarriage other than your normal risk factors. Do not need to follow folate (folic acid) or homocysteine levels. Read more...
No. Mthfr 677 does not affect colorectal cancer risk although it can increase risk of certain other cancers. Titrate folate (folic acid) intake to homocysteine level. If homocysteine is between 5-7, your folate (folic acid) intake is adequate. Do not take Folic Acid but rather take metafolin. http://drfairchild.blogspot.com/2013/08/homocysteine.html. Read more...
Junk science. Forgive my frankness. C677t is a no big deal & 10% of folks are like you. Eat sensibly &/or take folate (folic acid) if you want to conceive like anyone else. The push for mthfr typing is the work of a militant lab & i doubt its usefulness. I saw the little study from red china correlating this allele to lung cancer; it makes no sense biologically and the numbers are barely significant; i'm ignoring it. Read more...

33 y/o F. Homocysteine 11.45 Heterozygous MTHFR c677t. Is my homocysteine too high? Noticing different lab's values vary greatly, and are conflicting

No. It is border line. Don't compare normals in various labs. Only ur level to that lab. normals. Also check ur vir b12, folic acid and pyridoxine levels. Don't dx ur self. If early stroke or other signs read in web then see a specialist may cardiologist . Read more...

I had an mthfr test ran and they found a single copy of the c677t but no a1298c. Could this be causing my infertility?

No. Mthfr mutations have been associated with recurrent miscarriage. The linkage is very weak and not even be real. Even if they do, you need to have 2 mutations which you do not. They do not cause infertility. Read more...
Not so. Mthfr is not a primary cause for infertility. The single copy of 677 does promote less ability to make glutathione and increase inflammation. Consider a supplement called homocysteine factors. Read more...

recently diagnosed with MTHFR C677T, have B12 >2000 and high WBC and BP has gone from 90 over 70 to 120 over 78. Chaned diet to Paleo still in pain?

Homocysteine level . there is much non-evidence-based information about MThfr mutations. It is clear that the mutation you have puts you at significant risk of homocysteinuria. which increases your risk of stroke.B12 is not the first supplement you need – folinic acid or methyl folate (folic acid) should correct the homocystinuria. I suggest a consult with a metabolic or biochemical geneticist. Read more...
I'd take it easy. Up to 20% of folks in many communities have C677T allele. There's talk of it being a risk for this-or-that but this looks to me like just statistician junk. High B12's are never a concern in the absence of obvious myeloproliferative disease; are all you WBC's normal? is there any sign of polycythemia? BP fluctuates wildly; be thankful yours is normal. Look elsewhere for cause / help with your pain. Read more...

I had a miscarage last year at 14 weeks I have mthfr c677t heterozigot pozitive, pai 1 675 and pai 844 heterozigot positive. Could that be the reason?

Possibly. I am not an expert in this by any means, but I do know that women who have "thrombophilias, " the tendency to form blood clots, have a higher risk of pregnancy loss. You must remember that the miscarriage rate for all women is probably somewhere between one-in-three to one-in-five pregnancies. But i would recommend you discuss your lab work with hematologist and/or high-risk OB provider. Good luck. Read more...
Probably not. Testing for mthfr genotype is being promoted aggressively by one lab and a few physician-activists. Around half of women in many populations have at least one "abnormal gene." studies are mixed but on general medical principles, it seems unlikely that if blood homocysteine levels are normal that the gene is the problem. Carriers might benefit from extra folate, (folic acid) b6 &/or B12 supplementation. Read more...