I take nabumetone, methotrexate, enbrel, plaquenil, vitamin d and folic acid for RA & dermatomyo. Which of these is making it difficult to lose wight?

None of the above! Mtx, enbrel, (etanercept) ho-q, vit d3, and Folic Acid will not cause wt. Gain. Some fluid retention is not uncommon with nsaids, but it stops shortly after starting. I would suggest that your medication cocktale may be increasing appetite, and inactivity imposed on you by your illness is the most likely factor! arthritis patients frequently gain 5-6 lbs per year.

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Severe RA. Dr. prescribed Actemra (tocilizumab) inj. Plaqunil. Methotrexate. Sulfasalazine. Norco. Folic acid. What 2 watch out for? Any concerns from theses drugs?

Sounds right. Severe RA requires serious medications. I do not see any drug-drug problems. But individually these meds require monitoring and an awareness of what can go wrong. You absolutely must review your concerns with your doc who is paid to educate you about the risks and benefits of treatment and making an informed decision about your care. Read more...
All drugs have. side-effects, but this combination is usually well tolerated! Read more...

I'm being treated for RA with plaquenil, methotrexate, and Enbrel. My most recent blood work has low values of MPV 7.3 and MCHC 31.4.

Blood and RA meds. It is best to discuss these numbers with your rheumatologist. There are significant side effects of all these medications, although many other issues including diet and exercise may be another cause of the findings here. Serum folate levels may be of some value, and adjustment of the medications you are now on should be considered. Read more...

I have RA and I got small hand deformity am taking methotrexate every saturday and folic acid every sunday. Can that help stop the development?

Maybe. The evidence that Methotrexate alone can prevent damage is not that impressive. In patients with early damage i personally prescribe combination therapy with a tnf agent and methotrexate. Read more...
Yes, sometimes. Methotrexate is a first line therapy for RA in the us and most other therapies are combined with Methotrexate unless it cannot be used. If inflammation is continuing the addition of a biologic agent (humira, enbrel, (etanercept) simponi) may help prevent longterm damage. They have been shown to provide added benefit. Read more...