What body systems are affected by cornoary heart disease?

Mostly Heart. Coronary arteries are the main vessels coming off the aorta supplying blood to the heart muscle. There are 3 main coronary arteries. When they have significant plaques in them (coronary atherosclerosis, or coronary artery disease), people develop chest pains (angina), shortness of breath, chest tightness with exertion, heart attacks and various other consequences.