Is Accutane significantly more effective than over-the-counter products?

Yes. For patients with severe acne, Accutane is significantly more effective than over-the-counter (otc) products. But not all patients need accutane. In patients with mild acne, otc products such as salicyclic acid and benzoyl peroxide can help. If you have tried otc products, you should see your dermatologist who can prescribe stronger topical medications (such as retina) and oral antibiotics.