It depends? In most cases, no. Patients often report immediate relief from symptoms after transphenoidal hypophysectomy and little pain. Some leave the hospital the same day. This all depend on the surgery, possible complicatios.
Depends on size. Pituitary adenomas are now most commonly done via a transnasal endoscopic approach. The typical tumor that is 1-2cm and round in shape is removed readily. Patients tend to go home within 1-3 days. Cerebrospinal fluid leakage or problems with the hormones may prolong the hospital stay. The size of the tumor/how high it protrudes into the brain may make surgery more difficult and recovery slower.