Cancer. Malignant = cancer i can't think of an exception, but one may exist.
Transformation. When a normal cell transforms to malignancy a proto oncogene transforms to a complete oncogene producing a protein or proteins to allow the cell to become aggressive and invasive as well as immortal. A transcriptional protein like FGARAT appears allowing aggressiveness, followed by overexpression of telomerase for longevity, and then matrix metallo proteinase allowing blood vessel invasion.