6 doctors weighed in:

What causes low grade liposarcoma to upgrade to high grade liposarcoma?

6 doctors weighed in
Dr. Sabha Ganai
Surgery - Oncology
2 doctors agree

In brief: Hard to say

There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade.
There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas.

In brief: Hard to say

There are situations when a pathologist reviews the specimen again and finds higher grade "angrier" looking cells in the specimen - leading to an upgrade.
There are also situations when a liposarcoma recurs and the new tumor has "de-differentiated" or evolved into an angrier tumor. This can happen with time with certain aggressive liposarcomas.
Dr. Sabha Ganai
Dr. Sabha Ganai
Thank
Dr. Murthy Andavolu
Internal Medicine - Hematology & Oncology
2 doctors agree

In brief: Mutations

Genetic mutation(s) in the tumor can make it grow faster suddenly.

In brief: Mutations

Genetic mutation(s) in the tumor can make it grow faster suddenly.
Dr. Murthy Andavolu
Dr. Murthy Andavolu
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