Sometimes. Some colon cancers are related to specific genetic mutations but the majority are not.
It could be in some. 1 in 4 patients with colorectal cancer has a family history of colorectal cancer. 3 to 4 % of patients with colorectal cancer have 1 of 2 genetic syndromes caused by autosomal dominant genes: hereditary nonpolyposis colon cancer (hnpcc) and familial adenomatous polyposis (fap).
Are the people with family history/genetic factors the only ones who have colon cancer in their lower twenties?
No. The prevalence of identifiable genetic risk factors much higher among young people who get colon cancer. However, not all such young people have identifiable genetic risk factors. It's likely that many genetic abnormalities leading to cancer have not yet been discovered.
Colon cancer. Most colon cancer is spontaneous arising from polyps in the colon. There are some genetic causes such as hnpcc or lynch family syndrome. Deletion of dcc gene, puetz -jhegers, and some others.
Yes. If you have a strong family history of colon cancer in several 1st degree relatives, you may be a candidate for genetic testing, however if the test is negative it just means you do not have a genetic predisposition to colon cancer. 80% of colon cancers occur in individuals with no family history and hence would have a negative genetic test.
Yes. A common test is the colaris test for lynch syndrome available through myriad. Another panel called colonext offers an even broader spectrum of tests for high risk genes and is available through ambry genetics. Talk to a knowledgable physician or genetic counselor to know the implications and possible interpretations of the testing and to determine if you are a good candidate,
Colon cancer risk. While there is available genetic test to check for hereditary colon cancer, the best person to have this test is one with colon cancer or + strong family history -who is suspected to carry certain mutation i.e. Diagnosed at young age, family history of colon cancer or other multiple cancers history in the family. This test would not be suggested to everybody as a screening test for colon cancer.
If I have polyps in my colon, should I have genetic testing to see if I will likely have colon cancer?
Yes. Ask your GI specialist about your risks to have a genetic mutation causing gardner syndrome (dark pigmentation, eye, tooth changes) or lynch syndrome (colon polyps without other physical changes). Gene testing is available for both and if positive, indicates very high risk for recurring colon cancer that often prompts colectomy.
Maybe, maybe not. Depends on family history of colon polyps, ca, other cancers, e.g. Ovarian, types of kidney ca, , age of affected relatives, your age, number of polyps, types of polyp. Most cases of colon polyps and colon cancer are sporadic (not hereditary). Discuss with your gastroenterologist and primary doc.
Could help. A person does not inherit cancer per se from their parents but they could inherit genes that make it much more likely to develop it. Genetic tests currently available can identify some of those genes and help the patient and their families make right decisions. You are very young and if you have colon cancer, you should be seen by a professional with expertise in this matter. Best to you.
It may. There is a type of colon cancer for which the genes have been identified. This type of cancer is very aggressive so testing for the gene may be important. You should consult with your colon cancer specialist to determine if you need this test.
Are there any genetic tests required (other than kras) for a 30 year old female with stage iii-b colon cancer after surgery and before adjuvant chemo?
Not required... But someone so young with colon cancer should consider genetic testing for either non-polyposis or polyposis syndromes depending on the circumstances. This should be done by a specialist on genetic diseases. K-ras is done on cancer tissue whereas there others are blood tests. K-ras has to do with treatment of the cancer, the other tests can help choose treatment but mostly affect cancer risk.
MSI testing. Msi testing is routine at most centers to screen for lynch syndrome. Braf can also be a quick selection. Kras testing is currently not clinically used for early stage crc (1-3), given the negative adjuvant egfr agent trials.
I'm a 34 yr old female. My 63 y/o mother has colon cancer. Should I seek genetic testing? What are the pros/cons re: the genetic testing for me?
Screening yes. But not genetic testing, just having one family member is not an indication for genetic testing, how ever with that history you should have screening colonoscopy on regular basis. Good luck.