5 doctors weighed in:
Can thyroid adenoma develop into carcinoma?
5 doctors weighed in

2 doctors agree
In brief: No
A true thyroid adenoma is a benign tumor.
However, this can only be accurately assessed once it has been removed surgically -- not by fine needle aspiration. There are molecular alterations seen in carcinoma than are not seen in adenoma. However, some of the molecular changes are cumulative, like p53 mutations -- which are expressed in higher frequency in cancer.

In brief: No
A true thyroid adenoma is a benign tumor.
However, this can only be accurately assessed once it has been removed surgically -- not by fine needle aspiration. There are molecular alterations seen in carcinoma than are not seen in adenoma. However, some of the molecular changes are cumulative, like p53 mutations -- which are expressed in higher frequency in cancer.
Dr. Lester Thompson
Dr. Lester Thompson
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Dr. Mike Bowman
ENT - Head & Neck Surgery
2 doctors agree
In brief: Maybe
If you have a thyroid nodule that has "follicular cells" or has been labeled a "follicular neoplasm" by fna, you can't tell whether or not it is a carcinoma or adenoma.
The only way to know for sure is to remove it with surgery. Certain findings on ultrasound and increasing size of a nodule make it more concerning for a carcinoma.

In brief: Maybe
If you have a thyroid nodule that has "follicular cells" or has been labeled a "follicular neoplasm" by fna, you can't tell whether or not it is a carcinoma or adenoma.
The only way to know for sure is to remove it with surgery. Certain findings on ultrasound and increasing size of a nodule make it more concerning for a carcinoma.
Dr. Mike Bowman
Dr. Mike Bowman
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Dr. Barry Kahn
Pathology
In brief: Thyroid
The only way to differentiate between a follicular adenoma and follicular carcinoma of the thyroid is to remove the nodule surgically and carefully examine the periphery of the nodule for signs of invasion into/through the capsule or to find invasion of blood vessels/lymphatic spaces.

In brief: Thyroid
The only way to differentiate between a follicular adenoma and follicular carcinoma of the thyroid is to remove the nodule surgically and carefully examine the periphery of the nodule for signs of invasion into/through the capsule or to find invasion of blood vessels/lymphatic spaces.
Dr. Barry Kahn
Dr. Barry Kahn
Thank
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