4 doctors weighed in:

How is Down syndrome inherited?

4 doctors weighed in
Dr. William Goldie
Pediatrics - Neurology
2 doctors agree

In brief: Rarely

Downs syndrome is usually related to a trisomy defect that develops during the initial cleavage of the cells during primary fetal development.
A form can occur as a translocation that may be carried by a parent. An assumption is that the 21 chromosome may be damaged by maternal age or by some environmental factor that then results in downs syndrome. Most cases are just by chance.

In brief: Rarely

Downs syndrome is usually related to a trisomy defect that develops during the initial cleavage of the cells during primary fetal development.
A form can occur as a translocation that may be carried by a parent. An assumption is that the 21 chromosome may be damaged by maternal age or by some environmental factor that then results in downs syndrome. Most cases are just by chance.
Dr. William Goldie
Dr. William Goldie
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Dr. James Ferguson
Pediatrics

In brief: Usually not

The event is usually a new event, a defect where 3 #21 chromosomes end up in a baby instead of 2.
The female Down syndrome patient is fertile and potentially half her babies would have DS , but that is caused by passing on the extra chromosome, not like a trait like eye color.

In brief: Usually not

The event is usually a new event, a defect where 3 #21 chromosomes end up in a baby instead of 2.
The female Down syndrome patient is fertile and potentially half her babies would have DS , but that is caused by passing on the extra chromosome, not like a trait like eye color.
Dr. James Ferguson
Dr. James Ferguson
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